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Target
Mannose-6-phosphate isomerase
Ligand
BDBM34646
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM34646
Synonyms:
(1Z)-1-[[(1-methyl-2-benzimidazolyl)amino]methylidene]-2-naphthalenone | (1Z)-1-[[(1-methylbenzimidazol-2-yl)amino]methylene]naphthalen-2-one | (1Z)-1-[[(1-methylbenzimidazol-2-yl)amino]methylidene]naphthalen-2-one | MLS000106285 | SMR000103254 | cid_5332988
Type:
Small organic molecule
Emp. Form.:
C19H15N3O
Mol. Mass.:
301.3419
SMILES:
Cn1c(N=Cc2c(O)ccc3ccccc23)nc2ccccc12 |w:3.2|
Structure:
Search PDB for entries with ligand similarity: