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Target
Mannose-6-phosphate isomerase
Ligand
BDBM53636
Substrate
n/a
Meas. Tech.
HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
50000±n/a nM
Citation
 PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2009)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM53636
Synonyms:
(E)-N'-(2-fluorophenyl)-3-(3-quinolinyl)-2-propenohydrazide | (E)-N'-(2-fluorophenyl)-3-(3-quinolinyl)-2-propenehydrazide | (E)-N'-(2-fluorophenyl)-3-(3-quinolyl)acrylohydrazide | (E)-N'-(2-fluorophenyl)-3-quinolin-3-yl-prop-2-enehydrazide | (E)-N'-(2-fluorophenyl)-3-quinolin-3-ylprop-2-enehydrazide | MLS000721248 | SMR000335674 | cid_5875537
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O
Mol. Mass.:
307.3217
SMILES:
Fc1ccccc1NNC(=O)\C=C\c1cnc2ccccc2c1
Structure:
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