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Target
SUMO-conjugating enzyme UBC9
Ligand
BDBM44110
Substrate
n/a
Meas. Tech.
AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation
IC50
350±n/a nM
Citation
 PubChem, PC AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-conjugating enzyme UBC9
Synonyms:
UBC9 | UBC9_HUMAN | UBCE9 | UBE2I | ubiquitin-conjugating enzyme E2I
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18011.66
Organism:
Homo sapiens (Human)
Description:
gi_4507785
Residue:
158
Sequence:
MSGIALSRLAQERKAWRKDHPFGFVAVPTKNPDGTMNLMNWECAIPGKKGTPWEGGLFKLRMLFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIKQILLGIQELLNEPNIQDPAQAEAYTIYCQNRVEYEKRVRAQAKKFAPS
  
Inhibitor
Name:
BDBM44110
Synonyms:
(5Z)-3-[[(E)-(6-keto-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-5-[(5-methyl-2-furyl)methylene]-2-thioxo-thiazolidin-4-one | (5Z)-5-[(5-methyl-2-furanyl)methylidene]-3-[[(E)-(3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[(5-methylfuran-2-yl)methylidene]-3-[[(E)-(3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(5-methylfuran-2-yl)methylidene]-3-[[(E)-(3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-2-sulfanylidene-1,3-thiazolidin-4-one | 3-[(2-hydroxy-5-nitrobenzylidene)amino]-5-[(5-methyl-2-furyl)methylene]-2-thioxo-1,3-thiazolidin-4-one | MLS000673934 | SMR000297974 | cid_5891295
Type:
Small organic molecule
Emp. Form.:
C16H11N3O5S2
Mol. Mass.:
389.406
SMILES:
Cc1ccc(\C=C2/SC(=S)N(\[NH+]=C\[c-]3cc(ccc3=O)[N+]([O-])=O)C2=O)o1
Structure:
Search PDB for entries with ligand similarity: