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Target
Ras-related protein Rab-7a
Ligand
BDBM54605
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype
EC50
508±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related protein Rab-7a
Synonyms:
GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23519.50
Organism:
Canis lupus familiaris
Description:
gi_164058
Residue:
207
Sequence:
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKTSAESCSC
  
Inhibitor
Name:
BDBM54605
Synonyms:
1-[4-(difluoromethylsulfonyl)phenyl]-3,5-diphenyl-2-pyrazoline | 2-[4-(difluoromethylsulfonyl)phenyl]-3,5-diphenyl-3,4-dihydropyrazole | 2-[4-[bis(fluoranyl)methylsulfonyl]phenyl]-3,5-diphenyl-3,4-dihydropyrazole | UNM-0000305843 | cid_2857552
Type:
Small organic molecule
Emp. Form.:
C22H18F2N2O2S
Mol. Mass.:
412.452
SMILES:
FC(F)S(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccccc1)c1ccccc1 |c:14|
Structure:
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