Reaction Details
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Ras-related protein Rab-2A
Ligand
BDBM54631
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype
EC50
30000±n/a nM
Comments
Extracted from aid = 2045 and tid = 2
Citation
PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay (2016)[AID] More Info.:
Target
Name:
Ras-related protein Rab-2A
Synonyms:
RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A.
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23545.28
Organism:
Canis lupus familiaris
Description:
gi_46577642
Residue:
212
Sequence:
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNATHAGNQGGQQAGGGCC
Inhibitor
Name:
BDBM54631
Synonyms:
2-chloranyl-5-[3-(3,4-dimethoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzoic acid | 2-chloro-5-[3-(3,4-dimethoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzoic acid | 2-chloro-5-[5-(3,4-dimethoxyphenyl)-3-phenyl-2-pyrazolin-1-yl]benzoic acid | UNM-0000305872 | cid_2975283
Type:
Small organic molecule
Emp. Form.:
C24H21ClN2O4
Mol. Mass.:
436.888
SMILES:
COc1ccc(cc1OC)C1CC(=NN1c1ccc(Cl)c(c1)C(O)=O)c1ccccc1 |c:13|
Structure:
