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Target
GTPase KRas [1-37]
Ligand
BDBM54549
Substrate
n/a
Meas. Tech.
Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype
Ki
140±n/a nM
Citation
 PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
GTPase KRas [1-37]
Synonyms:
ras protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4034.04
Organism:
Homo sapiens (Human)
Description:
gi_190938
Residue:
37
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
  
Inhibitor
Name:
BDBM54549
Synonyms:
1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-propanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-1-one | KUC103356N | UNM-0000306070 | cid_25241706
Type:
Small organic molecule
Emp. Form.:
C23H26N4O2
Mol. Mass.:
390.4781
SMILES:
Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCc1nc(no1)-c1ccccc1
Structure:
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