Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM54623
Substrate
n/a
Meas. Tech.
Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype
Ki
10±n/a nM
Citation
 PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype PubChem Bioassay (2009)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM54623
Synonyms:
1-(2,5-dichlorophenyl)-3-(4-fluorophenyl)-5-(4-methoxyphenyl)-2-pyrazoline | 2-(2,5-dichlorophenyl)-5-(4-fluorophenyl)-3-(4-methoxyphenyl)-3,4-dihydropyrazole | 2-[2,5-bis(chloranyl)phenyl]-5-(4-fluorophenyl)-3-(4-methoxyphenyl)-3,4-dihydropyrazole | UNM-0000305862 | cid_25227385
Type:
Small organic molecule
Emp. Form.:
C22H17Cl2FN2O
Mol. Mass.:
415.288
SMILES:
COc1ccc(cc1)C1CC(=NN1c1cc(Cl)ccc1Cl)c1ccc(F)cc1 |c:11|
Structure:
Search PDB for entries with ligand similarity: