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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM33168
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B
EC50
1460±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM33168
Synonyms:
MLS000708356 | N-[5-[(4-chloranylphenoxy)methyl]-1,3,4-thiadiazol-2-yl]furan-2-carboxamide | N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-furamide | N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]-2-furancarboxamide | N-[5-[(4-chlorophenoxy)methyl]-1,3,4-thiadiazol-2-yl]furan-2-carboxamide | SMR000287823 | cid_921149
Type:
Small organic molecule
Emp. Form.:
C14H10ClN3O3S
Mol. Mass.:
335.766
SMILES:
Clc1ccc(OCc2nnc(NC(=O)c3ccco3)s2)cc1
Structure:
Search PDB for entries with ligand similarity: