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Target
Bcl-2-like protein 10 [11-204]
Ligand
BDBM54714
Substrate
n/a
Meas. Tech.
Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B
EC50
620±n/a nM
Citation
 PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B PubChem Bioassay (2009)[AID] 
Target
Name:
Bcl-2-like protein 10 [11-204]
Synonyms:
Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti-apoptotic protein NrH). | B2L10_HUMAN | BCL-B | BCL2L10 | BCLB | BOO | DIVA
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21981.77
Organism:
Homo sapiens (Human)
Description:
gi_23396469
Residue:
194
Sequence:
MADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
  
Inhibitor
Name:
BDBM54714
Synonyms:
3-chloranyl-4-[(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazolidin-4-yl)amino]-1-(4-methoxyphenyl)pyrrole-2,5-dione | 3-chloro-4-[(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolidinyl)amino]-1-(4-methoxyphenyl)pyrrole-2,5-dione | 3-chloro-4-[(1,5-dimethyl-3-oxo-2-phenylpyrazolidin-4-yl)amino]-1-(4-methoxyphenyl)pyrrole-2,5-dione | 3-chloro-4-[(3-keto-1,5-dimethyl-2-phenyl-pyrazolidin-4-yl)amino]-1-(4-methoxyphenyl)-3-pyrroline-2,5-quinone | UNM-0000306189 | cid_44203217
Type:
Small organic molecule
Emp. Form.:
C22H21ClN4O4
Mol. Mass.:
440.88
SMILES:
COc1ccc(cc1)-n1c(O)c(Cl)c(Nc2c(C)n(C)n(-c3ccccc3)c2=O)c1O
Structure:
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