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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM33049
Substrate
n/a
Meas. Tech.
uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay
IC50
6420±n/a nM
Citation
 PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay (2009)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM33049
Synonyms:
(4-chlorodithiazol-5-ylidene)-(3,5-dimethoxyphenyl)amine | 4-chloranyl-N-(3,5-dimethoxyphenyl)-1,2,3-dithiazol-5-imine | 4-chloro-N-(3,5-dimethoxyphenyl)-5-dithiazolimine | 4-chloro-N-(3,5-dimethoxyphenyl)dithiazol-5-imine | MLS000044018 | N-[(5Z)-4-chloro-5H-1,2,3-dithiazol-5-ylidene]-N-(3,5-dimethoxyphenyl)amine | SMR000021429 | cid_715724
Type:
Small organic molecule
Emp. Form.:
C10H9ClN2O2S2
Mol. Mass.:
288.774
SMILES:
COc1cc(OC)cc(c1)\N=c1\ssnc1Cl
Structure:
Search PDB for entries with ligand similarity: