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Target
Procathepsin L
Ligand
BDBM55149
Substrate
n/a
Meas. Tech.
QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC QFRET-based counterscreen for inhibitors of PFM18AAP: biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM55149
Synonyms:
3-nitro-5-(1,2,4-triazol-4-ylcarbamoyl)benzoic acid methyl ester | 3-nitro-5-[oxo-(1,2,4-triazol-4-ylamino)methyl]benzoic acid methyl ester | MLS001185466 | SMR000503129 | cid_1279661 | methyl 3-nitro-5-(1,2,4-triazol-4-ylcarbamoyl)benzoate
Type:
Small organic molecule
Emp. Form.:
C11H9N5O5
Mol. Mass.:
291.2197
SMILES:
COC(=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)Nn1cnnc1
Structure:
Search PDB for entries with ligand similarity: