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Target
Streptokinase A
Ligand
BDBM49440
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
48775±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM49440
Synonyms:
7-(4-hydroxy-3-methoxy-phenyl)-3-keto-5-methyl-2-(3-nitrobenzylidene)-7H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester | 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-2-[(3-nitrophenyl)methylidene]-3-oxo-7H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid ethyl ester | MLS000521548 | SMR000131956 | cid_4557301 | ethyl 7-(3-methoxy-4-oxidanyl-phenyl)-5-methyl-2-[(3-nitrophenyl)methylidene]-3-oxidanylidene-7H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate | ethyl 7-(4-hydroxy-3-methoxyphenyl)-5-methyl-2-[(3-nitrophenyl)methylidene]-3-oxo-7H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate
Type:
Small organic molecule
Emp. Form.:
C24H21N3O7S
Mol. Mass.:
495.504
SMILES:
CCOC(=O)C1=C(C)[N+]2=C([N-]C1c1ccc(O)c(OC)c1)S\C(=C/c1cccc(c1)[N+]([O-])=O)C2=O |c:5,8|
Structure:
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