Reaction Details Report a problem with these data
Target
Streptokinase A
Ligand
BDBM58070
Substrate
n/a
Meas. Tech.
Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression
EC50
150000±n/a nM
Citation
 PubChem, PC Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression PubChem Bioassay (2009)[AID] 
Target
Name:
Streptokinase A
Synonyms:
STRP_STRP1 | ska | streptokinase A precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49924.80
Organism:
Streptococcus pyogenes M1 GAS
Description:
gi_15675770
Residue:
440
Sequence:
MKNYLSIGVIALLFALTFGTVKSVQAIAGYGWLPDRPPINNSQLVVSMAGIVEGTDKKVFINFFEIDLTSQPAHGGKTEQGLSPKSKPFATDNGAMPHKLEKADLLKAIQKQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLKGHVRVRPYKEKPVQNQAKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKTHPGYTIYERDSSIVTHDNDIFRTILPMDQEFTYHVKNREQAYEINPKTGIKEKTNNTDLVSEKYYVLKQGEKPYDPFDRSHLKLFTIKYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFDIMDYTLTGKVEDNHDKNNRVVTVYMGKRPKGAKGSYHLAYDKDLYTEEERKAYSYLRDTGTPIPDNPKDK
  
Inhibitor
Name:
BDBM58070
Synonyms:
2-[(E)-[3-(3-methoxypropyl)-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-5-[(4-methylphenyl)amino]-1,3-oxazole-4-carbonitrile | 2-[(E)-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene]methyl]-5-(4-methylanilino)-1,3-oxazole-4-carbonitrile | 2-[(E)-[3-(3-methoxypropyl)-4-oxo-2-sulfanylidene-5-thiazolidinylidene]methyl]-5-(4-methylanilino)-4-oxazolecarbonitrile | 2-[(E)-[4-keto-3-(3-methoxypropyl)-2-thioxo-thiazolidin-5-ylidene]methyl]-5-(p-toluidino)oxazole-4-carbonitrile | 2-[3-(3-Methoxy-propyl)-4-oxo-2-thioxo-thiazolidin-(5E)-ylidenemethyl]-5-p-tolylamino-oxazole-4-carbon itrile | MLS000333371 | SMR000436724 | cid_2026614
Type:
Small organic molecule
Emp. Form.:
C19H18N4O3S2
Mol. Mass.:
414.501
SMILES:
COCCCN1C(=S)S\C(=C\c2nc(C#N)c(Nc3ccc(C)cc3)o2)C1=O
Structure:
Search PDB for entries with ligand similarity: