Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM40758
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
44230±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM40758
Synonyms:
(4-fluoro-1,3-benzothiazol-2-yl)-(5-phenyl-1,3,4-oxadiazol-2-yl)amine | 4-fluoro-N-(5-phenyl-1,3,4-oxadiazol-2-yl)-1,3-benzothiazol-2-amine | MLS000045467 | N-(4-fluoranyl-1,3-benzothiazol-2-yl)-5-phenyl-1,3,4-oxadiazol-2-amine | N-(4-fluoro-1,3-benzothiazol-2-yl)-5-phenyl-1,3,4-oxadiazol-2-amine | SMR000027224 | cid_3243386
Type:
Small organic molecule
Emp. Form.:
C15H9FN4OS
Mol. Mass.:
312.322
SMILES:
Fc1cccc2sc(Nc3nnc(o3)-c3ccccc3)nc12
Structure:
Search PDB for entries with ligand similarity: