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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM59272
Substrate
n/a
Meas. Tech.
uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay
EC50
71784±n/a nM
Citation
 PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM59272
Synonyms:
3-(3-phenyl-10H-pyridazino[4,3-b]quinoxalin-5-yl)propyl acetate | 3-(3-phenyl-10H-pyridazino[4,3-b]quinoxalin-5-yl)propyl ethanoate | Acetic acid 3-(3-phenyl-9H-1,2,9,10-tetraaza-anthracen-10-yl)-propyl ester | MLS000554886 | SMR000147003 | acetic acid 3-(3-phenyl-10H-pyridazino[4,3-b]quinoxalin-5-yl)propyl ester | cid_6407173
Type:
Small organic molecule
Emp. Form.:
C21H20N4O2
Mol. Mass.:
360.4091
SMILES:
CC(=O)OCCCN1c2ccccc2Nc2nnc(cc12)-c1ccccc1
Structure:
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