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Target
SUMO-activating enzyme subunit 1
Ligand
BDBM61190
Substrate
n/a
Meas. Tech.
uHTS HTRF assay for identification of inhibitors of SUMOylation
IC50
8520±n/a nM
Citation
 PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay (2010)[AID] 
Target
Name:
SUMO-activating enzyme subunit 1
Synonyms:
AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38440.84
Organism:
Homo sapiens (Human)
Description:
gi_17390638
Residue:
346
Sequence:
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
  
Inhibitor
Name:
BDBM61190
Synonyms:
MLS000713569 | N'-[(E)-(3,5-dibromo-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]isonicotinohydrazide | N'-[(E)-(3,5-dibromo-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]-4-pyridinecarbohydrazide | N'-[(E)-(3,5-dibromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]pyridine-4-carbohydrazide | N'-[(E)-[3,5-bis(bromanyl)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]pyridine-4-carbohydrazide | SMR000273050 | cid_5499874
Type:
Small organic molecule
Emp. Form.:
C13H9Br2N3O2
Mol. Mass.:
399.037
SMILES:
Oc1c(Br)cc(Br)cc1C=NNC(=O)c1ccncc1 |w:10.11|
Structure:
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