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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61291
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
78530±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61291
Synonyms:
6-(4-methyl-2-oxidanylidene-6-phenyl-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl)hexanoic acid | 6-(4-methyl-2-oxo-6-phenyl-5-phenylmethoxycarbonyl-1,6-dihydropyrimidin-3-yl)hexanoic acid | 6-(5-carbobenzoxy-2-keto-4-methyl-6-phenyl-1,6-dihydropyrimidin-3-yl)hexanoic acid | MLS000563539 | SMR000389067 | cid_5461618
Type:
Small organic molecule
Emp. Form.:
C25H28N2O5
Mol. Mass.:
436.5002
SMILES:
CC1=C(C(NC(=O)N1CCCCCC(O)=O)c1ccccc1)C(=O)OCc1ccccc1 |t:1|
Structure:
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