Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61320
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
36695±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61320
Synonyms:
(E)-N-[[4-(acetylcarbamothioylamino)phenyl]carbamothioyl]-3-(furan-2-yl)prop-2-enamide | (E)-N-[[4-(acetylthiocarbamoylamino)phenyl]thiocarbamoyl]-3-(2-furyl)acrylamide | (E)-N-[[4-(ethanoylcarbamothioylamino)phenyl]carbamothioyl]-3-(furan-2-yl)prop-2-enamide | (E)-N-[[4-[[acetamido(sulfanylidene)methyl]amino]anilino]-sulfanylidenemethyl]-3-(2-furanyl)-2-propenamide | 1-[4-(3-Acetyl-thioureido)-phenyl]-3-((E)-3-furan-2-yl-acryloyl)-thiourea | MLS000769752 | SMR000434485 | cid_1971610
Type:
Small organic molecule
Emp. Form.:
C17H16N4O3S2
Mol. Mass.:
388.464
SMILES:
CC(=O)NC(=S)Nc1ccc(NC(=S)NC(=O)C=Cc2ccco2)cc1 |w:18.18|
Structure:
Search PDB for entries with ligand similarity: