Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61358
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
31695±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61358
Synonyms:
(4E)-4-[(2,2-diphenylhydrazinyl)methylidene]-2,3-bis(oxidanyl)cyclohexa-2,5-dien-1-one | (4E)-4-[(2,2-diphenylhydrazinyl)methylidene]-2,3-dihydroxy-1-cyclohexa-2,5-dienone | (4E)-4-[(2,2-diphenylhydrazinyl)methylidene]-2,3-dihydroxycyclohexa-2,5-dien-1-one | (4E)-4-[(N',N'-diphenylhydrazino)methylene]-2,3-dihydroxy-cyclohexa-2,5-dien-1-one | MLS001172640 | SMR000589783 | cid_5824522
Type:
Small organic molecule
Emp. Form.:
C19H16N2O3
Mol. Mass.:
320.3419
SMILES:
Oc1ccc(C=NN(c2ccccc2)c2ccccc2)c(O)c1O |w:6.6|
Structure:
Search PDB for entries with ligand similarity: