Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM61389
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H)
IC50
50985±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2009)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM61389
Synonyms:
5-methyl-2-furancarboxylic acid [2-(cyclohexylamino)-2-oxoethyl] ester | 5-methylfuran-2-carboxylic acid [2-(cyclohexylamino)-2-keto-ethyl] ester | MLS001031748 | SMR000714670 | [2-(cyclohexylamino)-2-oxidanylidene-ethyl] 5-methylfuran-2-carboxylate | [2-(cyclohexylamino)-2-oxoethyl] 5-methylfuran-2-carboxylate | cid_2626055
Type:
Small organic molecule
Emp. Form.:
C14H19NO4
Mol. Mass.:
265.305
SMILES:
Cc1ccc(o1)C(=O)OCC(=O)NC1CCCCC1
Structure:
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