Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM61376
Substrate
n/a
Meas. Tech.
uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP)
IC50
11935±n/a nM
Citation
 PubChem, PC uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) PubChem Bioassay (2009)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM61376
Synonyms:
MLS001215335 | N-(2-Azepan-1-yl-2-oxo-ethyl)-N-(2,4-dimethoxy-phenyl)-2-nitro-benzenesulfonamide | N-[2-(1-azepanyl)-2-oxoethyl]-N-(2,4-dimethoxyphenyl)-2-nitrobenzenesulfonamide | N-[2-(azepan-1-yl)-2-keto-ethyl]-N-(2,4-dimethoxyphenyl)-2-nitro-benzenesulfonamide | N-[2-(azepan-1-yl)-2-oxidanylidene-ethyl]-N-(2,4-dimethoxyphenyl)-2-nitro-benzenesulfonamide | N-[2-(azepan-1-yl)-2-oxoethyl]-N-(2,4-dimethoxyphenyl)-2-nitrobenzenesulfonamide | SMR000608344 | cid_1117122
Type:
Small organic molecule
Emp. Form.:
C22H27N3O7S
Mol. Mass.:
477.531
SMILES:
COc1ccc(N(CC(=O)N2CCCCCC2)S(=O)(=O)c2ccccc2[N+]([O-])=O)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: