Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM45405
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM45405
Synonyms:
6-[(4-chloranyl-2,5-dimethoxy-phenyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid | 6-[(4-chloro-2,5-dimethoxy-phenyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid | 6-[(4-chloro-2,5-dimethoxyanilino)-oxomethyl]-1-cyclohex-3-enecarboxylic acid | 6-[(4-chloro-2,5-dimethoxyphenyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid | 6-{[(4-chloro-2,5-dimethoxyphenyl)amino]carbonyl}-3-cyclohexene-1-carboxylic acid | MLS000088563 | SMR000071846 | cid_3246787
Type:
Small organic molecule
Emp. Form.:
C16H18ClNO5
Mol. Mass.:
339.771
SMILES:
COc1cc(NC(=O)C2CC=CCC2C(O)=O)c(OC)cc1Cl |c:10|
Structure:
Search PDB for entries with ligand similarity: