Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM60023
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1).
IC50
>59642±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of M1 and M17 aminopeptidases: QFRET-based biochemical high throughput dose response assay for inhibitors of the Cathepsin L proteinase (CTSL1). PubChem Bioassay (2009)[AID] 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM60023
Synonyms:
MLS000698897 | N-(1,2-dihydro-5-acenaphthylenyl)-2-{[1-(4-fluorophenyl)-4-hydroxy-5-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl]sulfanyl}acetamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-[1-(4-fluorophenyl)-5-methyl-6-oxidanyl-4-oxidanylidene-pyrimidin-2-yl]sulfanyl-ethanamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-[1-(4-fluorophenyl)-6-hydroxy-5-methyl-4-oxopyrimidin-2-yl]sulfanylacetamide | N-(1,2-dihydroacenaphthylen-5-yl)-2-[[1-(4-fluorophenyl)-6-hydroxy-5-methyl-4-oxo-2-pyrimidinyl]thio]acetamide | N-acenaphthen-5-yl-2-[[1-(4-fluorophenyl)-6-hydroxy-4-keto-5-methyl-pyrimidin-2-yl]thio]acetamide | SMR000226482 | cid_1208700
Type:
Small organic molecule
Emp. Form.:
C25H20FN3O3S
Mol. Mass.:
461.508
SMILES:
Cc1c(O)nc(SCC(=O)Nc2ccc3CCc4cccc2c34)n(-c2ccc(F)cc2)c1=O
Structure:
Search PDB for entries with ligand similarity: