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Target
Regulator of G-protein signaling 8
Ligand
BDBM62219
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds
EC50
30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds PubChem Bioassay (2010)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM62219
Synonyms:
2,4-dimethyl-6-[2-oxidanylidene-2-(4-phenylpiperazin-1-yl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 6-[2-keto-2-(4-phenylpiperazino)ethyl]-2,4-dimethyl-7,8-dihydro-1,6-naphthyridin-5-one | KUC103674N | cid_44473130
Type:
Small organic molecule
Emp. Form.:
C22H26N4O2
Mol. Mass.:
378.4674
SMILES:
Cc1cc(C)c2C(=O)N(CC(=O)N3CCN(CC3)c3ccccc3)CCc2n1
Structure:
Search PDB for entries with ligand similarity: