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Target
Tumor necrosis factor
Ligand
BDBM62250
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
1630±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM62250
Synonyms:
1-[5-[4-(4-acetylphenyl)piperazin-1-yl]sulfonyl-2-methyl-2,3-dihydroindol-1-yl]propan-1-one | 1-[5-[4-(4-acetylphenyl)piperazino]sulfonyl-2-methyl-indolin-1-yl]propan-1-one | 1-[5-[4-(4-ethanoylphenyl)piperazin-1-yl]sulfonyl-2-methyl-2,3-dihydroindol-1-yl]propan-1-one | 1-[5-[[4-(4-acetylphenyl)-1-piperazinyl]sulfonyl]-2-methyl-2,3-dihydroindol-1-yl]-1-propanone | MLS-0412139.0001 | cid_44182144
Type:
Small organic molecule
Emp. Form.:
C24H29N3O4S
Mol. Mass.:
455.57
SMILES:
CCC(=O)N1C(C)Cc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(C)=O
Structure:
Search PDB for entries with ligand similarity: