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Target
Tumor necrosis factor
Ligand
BDBM54464
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction revised
IC50
19700±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction revised PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54464
Synonyms:
MLS001066639 | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitro-2-furamide | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitro-2-furancarboxamide | N-(4,6-difluoro-1,3-benzothiazol-2-yl)-5-nitrofuran-2-carboxamide | N-[4,6-bis(fluoranyl)-1,3-benzothiazol-2-yl]-5-nitro-furan-2-carboxamide | SMR000640856 | cid_2307752
Type:
Small organic molecule
Emp. Form.:
C12H5F2N3O4S
Mol. Mass.:
325.248
SMILES:
[O-][N+](=O)c1ccc(o1)C(=O)Nc1nc2c(F)cc(F)cc2s1
Structure:
Search PDB for entries with ligand similarity: