Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM62559
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM62559
Synonyms:
MLS000031545 | N-[2-(3,5-Dimethyl-pyrazol-1-yl)-2-oxo-ethyl]-2-phenyl-acetamide | N-[2-(3,5-dimethyl-1-pyrazolyl)-2-oxoethyl]-2-phenylacetamide | N-[2-(3,5-dimethylpyrazol-1-yl)-2-keto-ethyl]-2-phenyl-acetamide | N-[2-(3,5-dimethylpyrazol-1-yl)-2-oxidanylidene-ethyl]-2-phenyl-ethanamide | N-[2-(3,5-dimethylpyrazol-1-yl)-2-oxoethyl]-2-phenylacetamide | SMR000011650 | cid_652231
Type:
Small organic molecule
Emp. Form.:
C15H17N3O2
Mol. Mass.:
271.3144
SMILES:
Cc1cc(C)n(n1)C(=O)CNC(=O)Cc1ccccc1
Structure:
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