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Target
Heat shock factor protein 1
Ligand
BDBM62591
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)
EC50
>195000±0 nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM62591
Synonyms:
(3Z)-2-ethyl-1,1-bis(oxidanylidene)-3-[oxidanyl(phenyl)methylidene]-1,2-benzothiazin-4-one | (3Z)-2-ethyl-3-[hydroxy(phenyl)methylene]-1,1-diketo-1,2-benzothiazin-4-one | (3Z)-2-ethyl-3-[hydroxy(phenyl)methylidene]-1,1-dioxo-1,2-benzothiazin-4-one | MLS000080023 | SMR000034324 | cid_5389212
Type:
Small organic molecule
Emp. Form.:
C17H15NO4S
Mol. Mass.:
329.37
SMILES:
CCN1C(C(=O)c2ccccc2)=C(O)c2ccccc2S1(=O)=O |t:12|
Structure:
Search PDB for entries with ligand similarity: