Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Ligand
BDBM64775
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1)
IC50
67047±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput dose response assay for inhibitors of Protein Phosphatase 1 (PP1) PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Synonyms:
PP-1A | PP1A_HUMAN | PPP1A | PPP1CA | Serine/threonine protein phosphatase PP1-alpha catalytic subunit | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | protein phosphatase 1, catalytic subunit, alpha isoform 3
Type:
PROTEIN
Mol. Mass.:
37510.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197827
Residue:
330
Sequence:
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
  
Inhibitor
Name:
BDBM64775
Synonyms:
5-Amino-4-oxo-3-p-tolyl-3,4-dihydro-thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester | 5-amino-3-(4-methylphenyl)-4-oxo-1-thieno[3,4-d]pyridazinecarboxylic acid ethyl ester | 5-amino-4-keto-3-(p-tolyl)thieno[3,4-d]pyridazine-1-carboxylic acid ethyl ester | MLS000528230 | SMR000120805 | cid_3153302 | ethyl 5-amino-3-(4-methylphenyl)-4-oxothieno[3,4-d]pyridazine-1-carboxylate | ethyl 5-azanyl-3-(4-methylphenyl)-4-oxidanylidene-thieno[3,4-d]pyridazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3S
Mol. Mass.:
329.374
SMILES:
CCOC(=O)c1nn(-c2ccc(C)cc2)c(=O)c2c(N)scc12
Structure:
Search PDB for entries with ligand similarity: