Reaction Details Report a problem with these data
Target
Tumor necrosis factor
Ligand
BDBM54378
Substrate
n/a
Meas. Tech.
SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2
IC50
16900±n/a nM
Citation
 PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54378
Synonyms:
MLS001045934 | N-[1-(2-Chloro-benzyl)-1H-benzoimidazol-2-yl]-propionamide | N-[1-(2-chlorobenzyl)benzimidazol-2-yl]propionamide | N-[1-[(2-chlorophenyl)methyl]-2-benzimidazolyl]propanamide | N-[1-[(2-chlorophenyl)methyl]benzimidazol-2-yl]propanamide | SMR000425174 | cid_914315
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3O
Mol. Mass.:
313.781
SMILES:
CCC(=O)Nc1nc2ccccc2n1Cc1ccccc1Cl
Structure:
Search PDB for entries with ligand similarity: