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Target
Tumor necrosis factor
Ligand
BDBM54369
Substrate
n/a
Meas. Tech.
HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction
IC50
1730±184 nM
Citation
 PubChem, PC HTS dose response assay for identification of inhibitors of TNFa-specific NF-kB induction PubChem Bioassay (2010)[AID] 
Target
Name:
Tumor necrosis factor
Synonyms:
Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha
Type:
Enzyme
Mol. Mass.:
25645.11
Organism:
Homo sapiens (Human)
Description:
P01375
Residue:
233
Sequence:
MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQREEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
  
Inhibitor
Name:
BDBM54369
Synonyms:
2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-6-phenyl-pyrimidin-4-ol | 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-6-phenyl-1H-pyrimidin-4-one | 2-[(7-methoxy-4-methyl-quinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one | 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-6-phenyl-1H-pyrimidin-4-one | MLS000777862 | SMR000414248 | cid_1002841
Type:
Small organic molecule
Emp. Form.:
C20H17N5O2
Mol. Mass.:
359.3813
SMILES:
COc1ccc2c(C)nc(Nc3nc(cc(=O)[nH]3)-c3ccccc3)nc2c1
Structure:
Search PDB for entries with ligand similarity: