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Target
NADPH oxidase 1
Ligand
BDBM41688
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1)
IC50
354±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based dose response assay to identify inhibitors of NADPH oxidase 1 (NOX1) PubChem Bioassay (2010)[AID] 
Target
Name:
NADPH oxidase 1
Synonyms:
MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NOH-1 | NOH1 | NOX-1 | NOX1 | NOX1_HUMAN
Type:
PROTEIN
Mol. Mass.:
64890.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_792877
Residue:
564
Sequence:
MGNWVVNHWFSVLFLVVWLGLNVFLFVDAFLKYEKADKYYYTRKILGSTLACARASALCLNFNSTLILLPVCRNLLSFLRGTCSFCSRTLRKQLDHNLTFHKLVAYMICLHTAIHIIAHLFNFDCYSRSRQATDGSLASILSSLSHDEKKGGSWLNPIQSRNTTVEYVTFTSIAGLTGVIMTIALILMVTSATEFIRRSYFEVFWYTHHLFIFYILGLGIHGIGGIVRGQTEESMNESHPRKCAESFEMWDDRDSHCRRPKFEGHPPESWKWILAPVILYICERILRFYRSQQKVVITKVVMHPSKVLELQMNKRGFSMEVGQYIFVNCPSISLLEWHPFTLTSAPEEDFFSIHIRAAGDWTENLIRAFEQQYSPIPRIEVDGPFGTASEDVFQYEVAVLVGAGIGVTPFASILKSIWYKFQCADHNLKTKKIYFYWICRETGAFSWFNNLLTSLEQEMEELGKVGFLNYRLFLTGWDSNIVGHAALNFDKATDIVTGLKQKTSFGRPMWDNEFSTIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
  
Inhibitor
Name:
BDBM41688
Synonyms:
1-[4-(diethylamino)phenyl]-3-[2-(trifluoromethyl)phenyl]urea | MLS000581189 | N-[4-(diethylamino)phenyl]-N'-[2-(trifluoromethyl)phenyl]urea | SMR000199802 | cid_2206190
Type:
Small organic molecule
Emp. Form.:
C18H20F3N3O
Mol. Mass.:
351.3661
SMILES:
CCN(CC)c1ccc(NC(=O)Nc2ccccc2C(F)(F)F)cc1
Structure:
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