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Target
Inward rectifier potassium channel 2
Ligand
BDBM65865
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
22296±23651 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65865
Synonyms:
(E)-N-[(4-methoxyphenyl)methyl]-3-phenyl-2-propen-1-amine;hydrochloride | (E)-N-[(4-methoxyphenyl)methyl]-3-phenyl-prop-2-en-1-amine;hydrochloride | (E)-N-[(4-methoxyphenyl)methyl]-3-phenylprop-2-en-1-amine;hydrochloride | MLS000999784 | N-(4-methoxybenzyl)-3-phenyl-2-propen-1-amine hydrochloride | SMR000498944 | [(E)-cinnamyl]-p-anisyl-amine;hydrochloride | cid_6464138
Type:
Small organic molecule
Emp. Form.:
C17H19NO
Mol. Mass.:
253.3389
SMILES:
COc1ccc(CNC\C=C\c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: