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Target
Inward rectifier potassium channel 2
Ligand
BDBM65870
Substrate
n/a
Meas. Tech.
Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1
IC50
26944±15068 nM
Citation
 PubChem, PC Confirmation dose response assay for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 PubChem Bioassay (2010)[AID] 
Target
Name:
Inward rectifier potassium channel 2
Synonyms:
Irk1 | KCNJ2_MOUSE | Kcnj2 | inward rectifier potassium channel 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48383.35
Organism:
Mus musculus
Description:
gi_6680530
Residue:
428
Sequence:
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
  
Inhibitor
Name:
BDBM65870
Synonyms:
(4-Methoxy-benzyl)-naphthalen-1-ylmethyl-amine | 1-(4-methoxyphenyl)-N-(1-naphthalenylmethyl)methanamine;oxalic acid | 1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine;oxalic acid | 1-naphthylmethyl(p-anisyl)amine;oxalic acid | CHEMBL1620289 | MLS001203677 | SMR000516138 | cid_17367817 | ethanedioic acid;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine
Type:
Small organic molecule
Emp. Form.:
C19H19NO
Mol. Mass.:
277.3603
SMILES:
COc1ccc(CNCc2cccc3ccccc23)cc1
Structure:
Search PDB for entries with ligand similarity: