Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM47304
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
>39841±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM47304
Synonyms:
3-(1-benzofuran-2-carbonyl)-4-hydroxy-1-(2-phenylethyl)-2-pyridin-4-yl-2H-pyrrol-5-one | 3-(1-benzofuran-2-ylcarbonyl)-4-oxidanyl-1-(2-phenylethyl)-2-pyridin-4-yl-2H-pyrrol-5-one | 3-[2-benzofuranyl(oxo)methyl]-4-hydroxy-1-(2-phenylethyl)-2-pyridin-4-yl-2H-pyrrol-5-one | 4-(1-benzofuran-2-ylcarbonyl)-3-hydroxy-1-(2-phenylethyl)-5-(4-pyridinyl)-1,5-dihydro-2H-pyrrol-2-one | 4-(benzofuran-2-carbonyl)-3-hydroxy-1-phenethyl-5-(4-pyridyl)-3-pyrrolin-2-one | MLS000663758 | SMR000293052 | cid_2945586
Type:
Small organic molecule
Emp. Form.:
C26H20N2O4
Mol. Mass.:
424.448
SMILES:
O=C(C1C(N(CCc2ccccc2)C(=O)C1=O)c1ccncc1)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: