Reaction Details Report a problem with these data
Target
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Ligand
BDBM66194
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3)
IC50
13708±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3): TR-FRET-based biochemical high throughput dose response assay to identify agonists of the interaction between peroxisome proliferator-activated receptor gamma (PPARg) and nuclear receptor co-repressor 2 (NCOR2) PubChem Bioassay (2010)[AID] 
Target
Name:
Isoform 2 of Nuclear receptor corepressor 2 (TRAC-1)
Synonyms:
CTG26 | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 (TRAC-1) | nuclear receptor corepressor 2 isoform 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
81401.89
Organism:
Homo sapiens (Human)
Description:
Q9Y618-2 gi_116256445
Residue:
766
Sequence:
MAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
  
Inhibitor
Name:
BDBM66194
Synonyms:
2-(2,4-dichlorophenyl)-3-(furan-2-carbonyl)-4-hydroxy-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one | 2-(2,4-dichlorophenyl)-3-(furan-2-ylcarbonyl)-4-oxidanyl-1-(oxolan-2-ylmethyl)-2H-pyrrol-5-one | 2-(2,4-dichlorophenyl)-3-[2-furanyl(oxo)methyl]-4-hydroxy-1-(2-oxolanylmethyl)-2H-pyrrol-5-one | 5-(2,4-Dichloro-phenyl)-4-(furan-2-carbonyl)-3-hydroxy-1-(tetrahydro-furan-2-ylmethyl)-1,5-dihydro-pyrrol-2-one | 5-(2,4-dichlorophenyl)-4-(2-furoyl)-3-hydroxy-1-(tetrahydrofurfuryl)-3-pyrrolin-2-one | MLS001217270 | SMR000612181 | cid_3152554
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2NO5
Mol. Mass.:
422.259
SMILES:
Clc1ccc(C2C(C(=O)c3ccco3)C(=O)C(=O)N2CC2CCCO2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: