Reaction Details Report a problem with these data
Target
Bcl-2-like protein 11
Ligand
BDBM66385
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis
EC50
24170±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Inhibitors of A1 Apoptosis PubChem Bioassay (2010)[AID] 
Target
Name:
Bcl-2-like protein 11
Synonyms:
B2L11_HUMAN | BCL2-like 11 isoform 1 | BCL2L11 | BIM
Type:
PROTEIN
Mol. Mass.:
22175.26
Organism:
Homo sapiens (Human)
Description:
EBI_101325
Residue:
198
Sequence:
MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH
  
Inhibitor
Name:
BDBM66385
Synonyms:
2-[3-cyano-4-(4-fluorophenyl)-6-phenyl-pyridin-2-yl]sulfanyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)ethanamide | 2-[3-cyano-4-(4-fluorophenyl)-6-phenylpyridin-2-yl]sulfanyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide | 2-[[3-cyano-4-(4-fluorophenyl)-6-phenyl-2-pyridinyl]thio]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide | 2-[[3-cyano-4-(4-fluorophenyl)-6-phenyl-2-pyridyl]thio]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide | 2-{[3-cyano-4-(4-fluorophenyl)-6-phenyl-2-pyridinyl]sulfanyl}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide | MLS000539044 | SMR000164122 | cid_1717753
Type:
Small organic molecule
Emp. Form.:
C24H18FN5OS2
Mol. Mass.:
475.561
SMILES:
CCc1nnc(NC(=O)CSc2nc(cc(-c3ccc(F)cc3)c2C#N)-c2ccccc2)s1
Structure:
Search PDB for entries with ligand similarity: