Reaction Details
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Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67105
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] More Info.:
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
Inhibitor
Name:
BDBM67105
Synonyms:
2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-1-piperazinyl]-N-(4-fluorophenyl)-2-phenylacetamide | 2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-N-(4-fluorophenyl)-2-phenyl-ethanamide | 2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazin-1-yl]-N-(4-fluorophenyl)-2-phenylacetamide | 2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazino]-N-(4-fluorophenyl)-2-phenyl-acetamide | SR-03000000774-1 | cid_4965796
Type:
Small organic molecule
Emp. Form.:
C26H26FN3O5S
Mol. Mass.:
511.565
SMILES:
Fc1ccc(NC(=O)C(N2CCN(CC2)S(=O)(=O)c2ccc3OCCOc3c2)c2ccccc2)cc1
Structure:
