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Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM67140
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
42286±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM67140
Synonyms:
6,7-dimethoxy-3-[[3-(2-methoxyphenyl)-1,2-oxazol-5-yl]methyl]-2-(morpholin-4-ylmethylidene)-1H-quinazolin-4-one | 6,7-dimethoxy-3-[[3-(2-methoxyphenyl)-5-isoxazolyl]methyl]-2-(4-morpholinylmethylidene)-1H-quinazolin-4-one | 6,7-dimethoxy-3-[[3-(2-methoxyphenyl)isoxazol-5-yl]methyl]-2-(morpholinomethylene)-1H-quinazolin-4-one | SR-03000001033-1 | cid_44202998
Type:
Small organic molecule
Emp. Form.:
C26H28N4O6
Mol. Mass.:
492.5237
SMILES:
COc1cc2nc(CN3CCOCC3)n(Cc3cc(no3)-c3ccccc3OC)c(=O)c2cc1OC
Structure:
Search PDB for entries with ligand similarity: