Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67919
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
520±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67919
Synonyms:
1-[4-(2,4-Dichloro-benzyloxy)-phenyl]-3-phenyl-thiourea | 1-[4-(2,4-dichlorobenzyl)oxyphenyl]-3-phenyl-thiourea | 1-[4-[(2,4-dichlorophenyl)methoxy]phenyl]-3-phenyl-thiourea | 1-[4-[(2,4-dichlorophenyl)methoxy]phenyl]-3-phenylthiourea | MLS000555361 | SMR000172461 | cid_1143231
Type:
Small organic molecule
Emp. Form.:
C20H16Cl2N2OS
Mol. Mass.:
403.325
SMILES:
Clc1ccc(COc2ccc(NC(=S)Nc3ccccc3)cc2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: