Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM63711
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
450±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM63711
Synonyms:
MLS001002830 | N-[3-(dimethylsulfamoyl)-4-methyl-phenyl]-2-keto-chromene-3-carboxamide | N-[3-(dimethylsulfamoyl)-4-methyl-phenyl]-2-oxidanylidene-chromene-3-carboxamide | N-[3-(dimethylsulfamoyl)-4-methylphenyl]-2-oxo-1-benzopyran-3-carboxamide | N-[3-(dimethylsulfamoyl)-4-methylphenyl]-2-oxochromene-3-carboxamide | SMR000370791 | cid_3903461
Type:
Small organic molecule
Emp. Form.:
C19H18N2O5S
Mol. Mass.:
386.422
SMILES:
CN(C)S(=O)(=O)c1cc(NC(=O)c2cc3ccccc3oc2=O)ccc1C
Structure:
Search PDB for entries with ligand similarity: