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Target
Amyloid-beta A4 precursor protein-binding family A member 1
Ligand
BDBM50158
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2
IC50
5700±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Amyloid-beta A4 precursor protein-binding family A member 1
Synonyms:
APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92603.32
Organism:
Rattus norvegicus
Description:
gi_2625023
Residue:
839
Sequence:
MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPPPPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQDLERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIEEVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITPLHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPSKNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI
  
Inhibitor
Name:
BDBM50158
Synonyms:
(2E,3Z)-2-[ethoxy(hydroxy)methylene]-3-(4-propylbenzylidene)tetralin-1,4-quinone | (2E,3Z)-2-[ethoxy(hydroxy)methylidene]-3-[(4-propylphenyl)methylidene]naphthalene-1,4-dione | (2E,3Z)-2-[ethoxy(oxidanyl)methylidene]-3-[(4-propylphenyl)methylidene]naphthalene-1,4-dione | MLS000571357 | SMR000193442 | cid_5337202 | ethyl 1-hydroxy-4-oxo-3-(4-propylbenzylidene)-3,4-dihydro-2-naphthalenecarboxylate
Type:
Small organic molecule
Emp. Form.:
C23H22O4
Mol. Mass.:
362.4184
SMILES:
CCCc1ccc(CC2=C(C(=O)OCC)C(=O)c3ccccc3C2=O)cc1 |c:8|
Structure:
Search PDB for entries with ligand similarity: