Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM48335
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
16110±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM48335
Synonyms:
7,9-bis(chloranyl)-3-ethyl-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)sulfanyl-chromeno[2,3-d]pyrimidine-4,5-dione | 7,9-dichloro-3-ethyl-2-(2-morpholin-4-yl-2-oxoethyl)sulfanylchromeno[2,3-d]pyrimidine-4,5-dione | 7,9-dichloro-3-ethyl-2-[(2-keto-2-morpholino-ethyl)thio]chromeno[2,3-d]pyrimidine-4,5-quinone | 7,9-dichloro-3-ethyl-2-[[2-(4-morpholinyl)-2-oxoethyl]thio][1]benzopyrano[2,3-d]pyrimidine-4,5-dione | MLS000040477 | SMR000043996 | cid_663330
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O5S
Mol. Mass.:
470.326
SMILES:
CCn1c(SCC(=O)N2CCOCC2)nc2oc3c(Cl)cc(Cl)cc3c(=O)c2c1=O
Structure:
Search PDB for entries with ligand similarity: