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Target
Heat shock factor protein 1
Ligand
BDBM71701
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM71701
Synonyms:
8-fluoranyl-5-methyl-3-(2-morpholin-4-ylethyl)pyrimido[5,4-b]indol-4-one | 8-fluoro-5-methyl-3-(2-morpholin-4-ylethyl)pyrimido[5,4-b]indol-4-one | 8-fluoro-5-methyl-3-(2-morpholinoethyl)pyrimid[5,4-b]indol-4-one | 8-fluoro-5-methyl-3-[2-(4-morpholinyl)ethyl]-4-pyrimido[5,4-b]indolone | MLS000042189 | SMR000047318 | cid_666142
Type:
Small organic molecule
Emp. Form.:
C17H19FN4O2
Mol. Mass.:
330.3568
SMILES:
Cn1c2ccc(F)cc2c2ncn(CCN3CCOCC3)c(=O)c12
Structure:
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