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Target
Heat shock factor protein 1
Ligand
BDBM71924
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
>260000±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM71924
Synonyms:
2-phenyl-4-(phenylsulfanyl)-6-[(phenylsulfinyl)methyl]pyrimidine | 2-phenyl-4-phenylsulfanyl-6-(phenylsulfinylmethyl)pyrimidine | 4-(benzenesulfinylmethyl)-2-phenyl-6-(phenylthio)pyrimidine | 4-(benzenesulfinylmethyl)-2-phenyl-6-phenylsulfanylpyrimidine | MLS000540329 | SMR000125587 | cid_2769224
Type:
Small organic molecule
Emp. Form.:
C23H18N2OS2
Mol. Mass.:
402.532
SMILES:
O=S(Cc1cc(Sc2ccccc2)nc(n1)-c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: