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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73166
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
21400±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73166
Synonyms:
1-[oxo(thiophen-2-yl)methyl]-N-phenyl-4-piperidinecarboxamide | MLS-0435551.0001 | N-phenyl-1-(2-thenoyl)isonipecotamide | N-phenyl-1-(thiophene-2-carbonyl)piperidine-4-carboxamide | N-phenyl-1-thiophen-2-ylcarbonyl-piperidine-4-carboxamide | cid_1075464
Type:
Small organic molecule
Emp. Form.:
C17H18N2O2S
Mol. Mass.:
314.402
SMILES:
O=C(Nc1ccccc1)C1CCN(CC1)C(=O)c1cccs1
Structure:
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