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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73200
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
>100000±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73200
Synonyms:
MLS-0435567.0001 | N-[(Z)-[4-[2-(3,4-dimethylanilino)-2-keto-ethoxy]-3-methoxy-benzylidene]amino]-4-methoxy-benzamide | N-[(Z)-[4-[2-(3,4-dimethylanilino)-2-oxoethoxy]-3-methoxyphenyl]methylideneamino]-4-methoxybenzamide | N-[(Z)-[4-[2-[(3,4-dimethylphenyl)amino]-2-oxidanylidene-ethoxy]-3-methoxy-phenyl]methylideneamino]-4-methoxy-benzamide | cid_5434131
Type:
Small organic molecule
Emp. Form.:
C26H27N3O5
Mol. Mass.:
461.5097
SMILES:
COc1ccc(cc1)C(=O)N\N=C/c1ccc(OCC(=O)Nc2ccc(C)c(C)c2)c(OC)c1
Structure:
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