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Target
G protein-activated inward rectifier potassium channel 1
Ligand
BDBM36882
Substrate
n/a
Meas. Tech.
Measurement of GPCR-mediated thallium flux through GIRK channels: Dose-Response with Rauwolscine
EC50
12640±n/a nM
Citation
 PubChem, PC Measurement of GPCR-mediated thallium flux through GIRK channels: Dose-Response with Rauwolscine PubChem Bioassay (2010)[AID] 
Target
Name:
G protein-activated inward rectifier potassium channel 1
Synonyms:
Girk1 | KCNJ3_RAT | Kcnj3 | Kga
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56581.73
Organism:
Rattus norvegicus
Description:
gi_13928834
Residue:
501
Sequence:
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQGPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEVVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDISTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGPTRMEGNLPAKLRKMNSDRFT
  
Inhibitor
Name:
BDBM36882
Synonyms:
3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5,7-bis(oxidanyl)-2-(trifluoromethyl)chromen-4-one | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5,7-dihydroxy-2-(trifluoromethyl)-1-benzopyran-4-one | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5,7-dihydroxy-2-(trifluoromethyl)chromen-4-one | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5,7-dihydroxy-2-(trifluoromethyl)chromone | MLS000038402 | SMR000035462 | cid_5389033
Type:
Small organic molecule
Emp. Form.:
C18H11F3O6
Mol. Mass.:
380.2715
SMILES:
Oc1cc(O)c2c(c1)oc(c(-c1ccc3OCCOc3c1)c2=O)C(F)(F)F
Structure:
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