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Target
Importin subunit alpha-1
Ligand
BDBM74610
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74610
Synonyms:
2-(methylthio)-3-pyridinecarboxylic acid [2-(2-benzofuranyl)-2-oxoethyl] ester | 2-(methylthio)nicotinic acid [2-(benzofuran-2-yl)-2-keto-ethyl] ester | MLS000055370 | SMR000065908 | [2-(1-benzofuran-2-yl)-2-oxidanylidene-ethyl] 2-methylsulfanylpyridine-3-carboxylate | [2-(1-benzofuran-2-yl)-2-oxoethyl] 2-methylsulfanylpyridine-3-carboxylate | cid_2336404
Type:
Small organic molecule
Emp. Form.:
C17H13NO4S
Mol. Mass.:
327.354
SMILES:
CSc1ncccc1C(=O)OCC(=O)c1cc2ccccc2o1
Structure:
Search PDB for entries with ligand similarity: