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Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM74449
Substrate
n/a
Meas. Tech.
Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM74449
Synonyms:
8-bromanyl-4-piperidin-1-yl-pyrimido[4,5-b][1,4]benzoxazepine | 8-bromo-4-(1-piperidinyl)pyrimido[4,5-b][1,4]benzoxazepine | 8-bromo-4-piperidin-1-ylpyrimido[4,5-b][1,4]benzoxazepine | 8-bromo-4-piperidino-pyrimido[4,5-b][1,4]benzoxazepine | MLS000079250 | SMR000039282 | cid_658364
Type:
Small organic molecule
Emp. Form.:
C16H15BrN4O
Mol. Mass.:
359.22
SMILES:
Brc1ccc2Oc3ncnc(N4CCCCC4)c3N=Cc2c1 |c:20|
Structure:
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